Routine step: Treatment. After treatment/serum and before sunscreen.

If you're a beginner:
If you are not familiar with skincare products containing spicules, we recommend to start with 2000 PPM.

If you're expecrienced
Step 1. After cleansing, apply the Zero One Day Exosome Shot to your entire face, avoiding the area near your eyes and lips. For the best results, we recommend using the Exosome Shot as the first step in your skincare routine.

Step 2. Gently rub and press with your hands to ensure that the needle-like formula is absorbed deep into your skin.

Step 3. Finish with Medicube’s Collagen Jelly Cream (or your daily water-based moisturizer).

Pro tip! To maximize the effect, apply the Zero One Day Exosome Serum after using the "Air Shot Mode" of the AGE-R Booster Pro.

NOTE! Avoid applying near the eyes and lips. For sensitive and delicate skin, we recommend conducting a patch test before use. To achieve optimal efficacy, please familiarize yourself with the instructions for use. You may experience a tingling sensation, which may last for some time, but rest assured that this is a natural reaction to the Exosome Shot.

Pro tip! To maximize the effect apply Zero Excosome Shot Ampoule after using the "Air Shot Mode" on Age-R Booster Pro.

Skin types: Combination to oily skin. Sensitive skin should use 2000 PPM.

Skin concerns: Enlarged pores, excessive oiliness, post-acne spots, hyperpigmentation

Reduction in pore density, visibility and pore volume.

Texture: Milky fluid

Key Ingredients

Exosome-coated Spicule (Hydrolyzed sponge):Taking the form of needles, spicules penetrate the epidermal layer of the skin, providing next generation care for pores and overall healthier skin. While various skincare products feature Spicules, none are quite like Exosome Shot, which contains Exosome-coated Spicules.

Lacto Exosome: A patented active ingredient in Medicube, effectively cares for damaged skin, providing vitality and energy Comprised of various active ingredients including peptides, amino acids, glutathione, and vitamins, Medicube's patented Exosome addresses daily skin concerns and promotes natural skin health.

AHA + BHA + PHA: Powerhouse ingredients that aid in resurfacing textured skin, dissolving dead skin cells, and promoting skin renewal.

Niacinamide: Boosts the skin’s barrier and delivers hydration.

Panthenol: Soothes the skin and helps improve hydration levels.

INCI List: Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis (Evening Primrose) Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl/Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium EDTA, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone

Q. Is it normal for my face to tingle after application?

Exosome Shot Ampoule contains naturally derived micro-particle ingredients, which may cause a tingling sensation upon application. This is a natural reaction as the active ingredients are being delivered to the pores.
We recommend adjusting the amount and frequency of use based on individual skin sensitivity.

• Q. Do I simply wash it off or do I maintain my regular skincare routine afterwards?This product is not meant to be rinsed off.
  Instead, it acts as a pathway to enhance skincare absorption, increasing the uptake of active ingredients by 242% compared to using cosmetics alone.
• Q. What are exosomes, and what is the source and function of the Lacto Exosome in Zero Exosome Shot?Exosomes are tiny particles, similar to miniature bubbles, that are naturally produced by almost all types of cells. They are much smaller than cells and can carry a variety of important materials such as proteins, fats, and genetic information (like RNA).
  The Lacto Exosome in Medicube Exosome Shot is sourced from Lactobacillus, a type of beneficial bacteria that helps boost the immune system.
• Q. Will the Spicule(Hydrolyzed sponge) dissolve on the skin or be absorbed?The spicules are designed to naturally shed along with the dead skin over several days after application.
  Any residual product left behind will not be absorbed into your body; instead, it will naturally dissipate.
• Q. Are there any ingredients that should not be used together with it?There are no specific ingredients that should not be used together; however, individuals with sensitivity should be cautious as certain ingredients may cause irritation or hypersensitivity reactions.
  Please conduct a patch test and adjust the amount and frequency of use accordingly.
• Q. I want to focus on managing my pores. Are there any synergistic products that work well together?When used in conjunction with the Exosome Shot, the One-day Serum and One-day Cream result in an 88% improvement in pore volume and an 85% improvement in pore area compared to using the Exosome Shot alone. For more effective pore management, we recommend using the Exosome Shot Ampoule first, followed by the One-day Serum, and finishing with the One-day Cream.
  * Excerpts from in vivo absorption tests for improving skin absorption depth compared to using One-day Serum + One-day Cream alone. / Individual results may vary.